Plaque

Gouache and silverpoint, 15 x 22cm, 2013 This is partnered with Tangle

As we age we all accumulate gunky protein structures in our brains, some more than others. How they contribute to dementia is still open for debate and will be for some years yet. Why is it that some elderly people have a lot of plaques and no dementia while others develop dementia with very few plaques? If we can answer that question we will be very much closer to creating a treatment. Despite decades of research, we are, alas, many years away from answering the most basic questions around the role of the amyloid beta protein in dementia.